Table 1. Non-synonymous mutations in the S region of Palestinian D1 subgenotypes.

nt position	aa position	Occurrence	Reported function/detected in	Reference
410:A/T	I86F	1	Unknown/Chronic HBV carriers with D1 subgenotype	[63]
429:T/C	I92T	1	Unknown/Subgenotype C1	[64]
482:A/C	I110L	1	Unknown/solely anti-HBc-positive sera, genotype A	[34]
484:T/G	I110L	1	Unknown/solely anti-HBc-positive sera, genotype A	[34]
531: C/G	T126S	1	Escape mutation	[35]
533: C/T	P127S	1	Escape mutation	[36]
555:A/T	Y134F	2	Unknown/solely anti-HBc- positive sera, genotype D	[34]
581:T/A	S143T	1	Unknown/solely anti-HBc-positive sera, genotype D	[34]
586: C/A	D144E	2	Escape mutation	[37]
587: G/A	G145R	3	Escape mutation	[38]
720:C/T	T189I	1	Reduces HBsAg detection signal of genotype E	[65]
753:A/C	Y200F	1	Unknown/naïve patients	[64]
765:G/A	S204R	1	Unknown/genotype E	[34]
771:A/T	Y206L	1	Unknown	Novel
772:G/T	Y206L	1	Unknown	Novel
774:G/A	S207N	2	Unknown/solely anti-HBc-positive sera, genotype D	[34]
784:T/A	S210R	1	Unknown/genotype A	[34]
791:T/A	L213I	3	Unknown/genotypes D and C	[34]
791:T/A	L213F	1	Unknown/solely anti-HBc-positive sera, genotype D	[34]

Positions of the nucleotide (nt) mutation and the correlating amino acid (aa) are presented based on their location in the archived GenBank reference DQ315778. Occurrence reflects the number of samples (patients) in which the mutation was detected. Known escape mutations are in boldface. Exchanges marked with (*) are considered polymorphisms due to their prevalence in>10% of the 40 patients. Corresponding references and proposed functions are provided in the last two columns. Unreported mutations were considered novel.