Table 5. Non-synonymous mutations in the RT region of Palestinian D1 subgenotypes.

nt position	aa position	Occurrence	Reported function/detected in	Reference
400:C/A	L91I	1	Unknown/patients treated with NRTIs	[68]
410:A/T	H94I	1	Unknown	Novel
457:A/G	R110G	2	Unknown/naïve patients	[69]
472:T/G	L115V	1	Unknown/naïve patients	[70]
493:T/(A,C,G)	F122I	15*	Unknown	[71]
499:T/(C,A)	H124Y	9*	Unknown	[71]
533:A/C	Y135S	35*	Unknown/HIV-positive HBV patient after LVD therapy	[72]
533:A/T	Y135F	1	Unknown	Novel
538:T/A	S137T	2	Unknown	[71]
562:C/A	L145M	1	Unknown/naïve patient	[70]
586:C/A	R153K	2	Proposed to enhance viral polymerase fitness	[72]
587:G/A	R153Q	2	Reduces the replication efficiency of the viral polymerase.	[72]
784:T/(C,A)	S219P	2	Unknown/ETV-treated patients	[69]
791:T/A	F221Y	3	Unknown/naïve patients	[73]
793:A/T	T222S	1	Unknown/ETV-treated patients	[69]
823:C/A	P237T	1	Unknown/naïve patients	[73]
871:A/C	N248H	24*	Unknown/HIV-positive HBV patient after LVD therapy	[72]
895:T/A	C256S	2	Unknown	[71]
918:T/A	D263E	1	Unknown	[71]
926:T/(G,A)	I266K	3	Unknown/patients treated with NRTIs	[68]
950:G/A	R274K	4*	Unknown/NRTIs–naïve patients	[68]
965:A/C	N279T	1	Unknown	GenBank AB106564
1055:T/A	M309K	2	Impairs viral polymerase activity	[74]

Positions of the nucleotide (nt) mutation and the correlating amino acid (aa) are presented based on their location in the archived GenBank reference DQ315778. Occurrence reflects the number of samples (patients) in which the mutation was detected. Corresponding references and proposed functions are provided in the last two columns. Unreported mutations were considered novel. Exchanges marked with (*) are considered polymorphisms due to their prevalence in>10% of the 40 patients. NRTIs: nucleoside and/or nucleotide reverse-transcriptase inhibitors, LVD: Lamivudine, ETV:Entecavir.