Table 9. Non-synonymous mutations in the RT region of Palestinian A2 subgenotypes.
nt position | aa position | Occurrence | Reported function/detected in | Reference |
406:C/T | L93F | 1 | Unknown | Novel |
436:A/G | I103V | 1 | Unknown | GenBank AF143307 |
779:G/T | L217R | 3 | Unknown | [71] |
886:A/G | I253V | 3 | Unknown | [71] |
950:G/A | R274K | 1 | Unknown/NRTIs–naïve patients | [68] |
952:A/G | K275E | 1 | Unknown/ETV-treated patients | [69] |
Positions of the nucleotide (nt) mutation and the correlating amino acid (aa) are presented based on their location in the archived GenBank reference X51970. Corresponding references and proposed functions are provided in the last two columns. Unreported mutations were considered novel. NRTIs: nucleoside and/or nucleotide reverse-transcriptase inhibitors, ETV: Entecavir.