Table 4. Gene-based association analysis with lipid traits in African Blacks.
Gene-based test based on all genotyped SNPs | |||||||
Chr | Gene | nSNPs | Test | P-value | Best SNP | SNP p-value | |
HDL-C | 19 | APOE | 23 | 33.35805 | 0.122 | APOE618 | 0.00079 |
LDL-C | 19 | APOE | 23 | 97.16241 | 8.00E-06 | APOE4075/rs7412 | 5.35E-07 |
TG | 19 | APOE | 23 | 33.95383 | 0.124 | APOE73/rs1081101 | 0.009268 |
APOB | 19 | APOE | 23 | 32.04047 | 0.162 | APOE1163/rs440446 | 0.010931 |
nSNPs: represents the number of SNPs included in the analysis; Test: represent the overall test statistic; P-value: the overall p-value; SNP p-value: p-value of the best SNPs contributed to the significance.