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Presumed path of cortical spreading depression in patient 5.
Comment: The onset of aura with somatosensory symptoms points to the primary somatosensory cortex as the first site of origin of CSD, which radiates to the posterior parietal cortex, temporal lobe and Broca’s area. The origin site could be the primary visual cortex, located in the occipital lobe, from where CSD spreads to the parietal and temporal lobes, and then, possibly, to Broca’s area.
