Table 2.
Top 20 down-regulated microRNAs in the spleen after lymphotoxin β receptor (LTβR) -blockade identified by analysis on Affymetrix microRNA microarrays
| LTβR-Ig (dpi)1 |
||||
|---|---|---|---|---|
| MicroRNA | 0 | 2 | 14 | LTβ−/− |
| mmu-miR-708 | 1·00 | 0·78 | 0·64 | 0·20 |
| mmu-miR-138 | 1·00 | 0·98 | 0·48 | 0·36 |
| mmu-miR-2137 | 1·00 | 0·85 | 0·57 | 0·41 |
| mmu-miR-187 | 1·00 | 0·93 | 0·52 | 0·46 |
| mmu-miR-466h | 1·00 | 1·02 | 1·43 | 0·49 |
| mmu-miR-1893 | 1·00 | 0·80 | 0·66 | 0·50 |
| mmu-miR-762 | 1·00 | 0·76 | 0·59 | 0·50 |
| mmu-miR-100 | 1·00 | 0·78 | 0·72 | 0·53 |
| mmu-miR-1224 | 1·00 | 0·62 | 0·61 | 0·54 |
| mmu-miR-1937a | 1·00 | 0·92 | 0·79 | 0·56 |
| mmu-miR-139-3p | 1·00 | 1·20 | 0·77 | 0·56 |
| mmu-miR-1894-3p | 1·00 | 0·66 | 0·69 | 0·57 |
| mmu-miR-1937b | 1·00 | 0·84 | 0·82 | 0·58 |
| mmu-miR-2133 | 1·00 | 0·99 | 0·63 | 0·60 |
| mmu-miR-151-3p | 1·00 | 0·84 | 0·73 | 0·61 |
| mmu-miR-193b | 1·00 | 1·10 | 0·66 | 0·62 |
| mmu-miR-1959 | 1·00 | 0·59 | 0·68 | 0·63 |
| mmu-miR-466f | 1·00 | 1·20 | 1·12 | 0·66 |
| mmu-miR-455 | 1·00 | 0·97 | 0·94 | 0·67 |
| mmu-miR-19a | 1·00 | 1·30 | 1·45 | 0·67 |
MicroRNAs in bold type indicate those also identified using Exiqon microRNA microarrays.
1
Fold-change in expression level when compared with untreated wild-type mice (d 0). Dpi, day post intraperitoneal injection with LTβR-Ig.