Figure 4.

RtcB is required for the unfolded protein response

A RNAseq read coverage at the xbp-1 locus in poly-A-selected, tunicamycin-treated, RtcB null worms.

B Fold change per gene for genes that exhibit a ≥ 1.75 fold change in control worms, comparing untreated to tunicamycin-treated animals. Genes are ranked by fold change in control, shown in blue; pink bars indicate the fold change in RtcB mutants.

C Same analysis as (B), except genes are selected that exhibit a ≥ 1.75 fold change in RtcB mutants. Genes are ranked by fold change in RtcB mutants, shown in pink; blue bars indicate the fold change in control animals.

Data information: Data and gene names are listed in Supplementary Tables S2 and S3