Figure 5.

TXNIP repression is required for the oncogenic switch by miR-224/452

A, B Overexpression of TXNIP in aggressive melanoma cells with low endogenous levels reduces migration and invasion.

C Effect of ectopic TXNIP on EMT markers in SK-Mel-147 and SK-Mel-103 cells as indicated by Western blot.

D MiR-224/452-induced invasion is inhibited by TXNIP. TXNIP expression was determined by immunoblot using actin as a control. Fold changes were calculated relative to SK-Mel-29.miR-Scr (set as 1).

Data information: Bar graphs are represented as means ± SD, n = 3 (A) or n = 5 (B, D), *P ≤ 0.05, two-sided Student's t-test.