Figure 6.

Loss of TXNIP due to aberrant E2F1-miR-224/452 expression is crucial for transcription factor-mediated cancer progression

A–C E2F1-induced EMT and invasion requires downregulation of TXNIP by miR-224/452. Invasion was measured by Boyden chamber, and fold changes were calculated relative to the controls (set as 1). Expression of indicated proteins is shown by Western blot.

Data information: Bar graphs are represented as means ± SD, n = 3 (A) or n = 5 (B), *P ≤ 0.05, two-sided Student's t-test.