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. 2014 Dec 12;9(12):e115404. doi: 10.1371/journal.pone.0115404

Figure 3. Effect of different commercial parenteral lipid emulsions on Lipopolysaccharide (LPS)-induced IL-6 and TNFα secretion in human monocytes.

Figure 3

Human monocytes were isolated from healthy subjects and incubated in presence or absence of lipid emulsions Omegaven® 10%, Lipofundin MCT/LCT® 20%, ClinOleic® 20% or SMOFlipid® 20% at different dilutions, for 30 min followed by LPS 1 µg/mL stimulation for additional 24 hours. (A) IL-6 and (B) TNFα were measured in cell culture supernatants. The effect of lipid emulsions without stimulus was tested at 1/10 dilution. Results are expressed as means ± SEM of six independent experiments. *p<0.05 related to the control group. #p<0.05 values below stimulus; ⊥p<0.05 values above the stimulus.