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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: J Mol Cell Cardiol. 2014 Apr 30;74:64–75. doi: 10.1016/j.yjmcc.2014.04.014

Figure 9. Calculated cross-bridge distributions based on equilibrium constants in Fig. 8A at the standard activating condition.

Figure 9

([Pi]=8 mM, [MgATP]=5 mM, [MgADP]=0.02 mM). All the cross-bridge states are defined in Scheme S1 in Supporting Materials, where A=actin, M=myosin, S=ATP, D=ADP, and P=phosphate. Det indicates the sum of weakly attached states (AMS, AMDP) and detached states (MS, MDP). Att indicates the sum of all strongly attached (force generating) cross-bridges: Att=AMD+AM+AM*S+AM*DP+AM*D. #Significantly different from native fibers (p<0.05). The distribution was calculated on each fiber, and averaged among the fibers.