Table 4.
End-point plasma glucose control, inflammatory markers, hepatic lipids, and oxidative enzyme activities.
| N | HFD | RN | 1 × AP | 2 × AP | |
|---|---|---|---|---|---|
| FBS (mg/dL) | 139.0 ± 7.1b | 171.3 ± 5.6a | 161.6 ± 8.2a | 141.0 ± 2.1b | 133.6 ± 7.4b |
| Insulin (μg/L) | 0.21 ± 0.04b | 1.20 ± 0.25a | 0.38 ± 0.20b | 0.29 ± 0.07b | 0.22 ± 0.04b |
| HOMA-IR | 1.7 ± 0.4b | 7.9 ± 2.4a | 4.2 ± 2.5ab | 2.5 ± 0.6b | 1.9 ± 0.4b |
| Vit E (μg/mL) | 20.8 ± 1.0a | 15.8 ± 0.7b | 17.7 ± 1.2ab | 20.0 ± 1.7a | 21.2 ± 1.9a |
| Vit C (μM) | 453.9 ±8.0bc | 388.3 ± 12.7d | 414.0 ± 17.0cd | 476.4 ± 27.4ab | 532.9 ± 37.5a |
| TNF-α (ng/mL) | 1.8 ± 0.0bc | 3.2 ± 0.4a | 2.7 ± 0.5ab | 1.2 ± 0.2c | 1.2 ± 0.2c |
| IL-6 (ng/mL) | 21.2 ± 2.2b | 48.8 ± 5.8a | 34.8 ± 7.2ab | 25.1 ± 3.2b | 23.0 ± 2.8b |
| Hepatic lipids | |||||
| cholesterol (mg/g) | 2.7 ± 0.2c | 28.7 ± 3.5a | 12.0 ± 2.6b | 4.9 ± 1.1c | 5.5 ± 1.8c |
| triglyceride (mg/g) | 4.5 ± 0.2c | 19.1 ± 1.4a | 8.8 ± 0.6b | 8.4 ± 0.9b | 6.4 ± 0.8bc |
| Hepatic oxidative status | |||||
| SOD (U/mg) | 210.0 ± 12.0a | 142.2 ± 11.9b | 187.3 ±11.0ab | 172.9 ± 32.8ab | 206.1 ± 34.2a |
| GR (nmol/min/mg) | 20.2 ± 3.3a | 10.9 ± 1.2b | 12.5 ± 2.1ab | 14.9 ± 2.4ab | 19.8 ± 3.5a |
| Catalase (nmol/min/mg) | 2032.6 ±384.1b | 3111.8 ± 250.2a | 1664.0 ± 173.2b | 1545.6 ± 166.4b | 1804.4 ±162.4b |
| GPX (nmol/min/mg) | 605.8 ± 85.5a | 351.9 ± 16.0c | 344.9 ± 23.4c | 398.7 ± 14.7bc | 511.8 ± 46.7ab |
| Vit E (μg/g) | 63.4 ± 7.8a | 14.1 ± 2.0d | 18.8 ± 2.2cd | 29.8 ± 3.4bc | 34.2 ± 3.1b |
| MDA (μmol/g) | 687.3 ± 62.2c | 1433.5 ± 59.8a | 933.7 ± 43.6b | 740.1 ± 45.9c | 699.6 ± 58.1c |
Data presented as mean ± SEM.
Superscripts represent statistically significant differences among groups. p <0.05 N, normal dietary group; HFD, high-fat diet group; RN, normal diet reversion group; 1× and 2× AP, normal diet recovery supplemented with 0.75% (w/w) and 1.5% (w/w) of Auricularia polytricha water extract, respectively.FBS, fasting blood sugar; HOMA-IR, homeostatic model assessment- insulin resistance; TNF, tumor necrosis factor; IL, interleukin; SOD, superoxide dismutase; GR, glutathione reductase; GPx, glutathione peroxidase; MDA, malondialdehyde.