Table 1.
List of siRNA Targets in Intimal Hyperplasia.
| Target | Mechanism | Study Type | References |
|---|---|---|---|
| Growth Factors | |||
| TGF-beta1 – SMAD3 and CTGF | VSMC proliferation and migration, MMP modulation, ECM remodeling | Rat model, in vitro | Sun et al., 2012; Suwanabol et al., 2012a; Kundi et al., 2009 |
| ATF / EGFR / Nox1 | VSMC migration, ROS production | In vitro | Bakken et al., 2009; Duru et al., 2012 |
| IGF-1 / CIC-2 / AngII / Cx43 | VSMC proliferation and migration | In vitro | Cheng et al., 2007; Jia et al., 2008; Jia et al., 2011 |
| Midkine | Cell migration, inflammation | Rabbit model | Banno et al., 2006 |
| Transcription Factors and Cell Cycle Regulators | |||
| E2F | VSMC growth | Mouse model, in vitro | Giangrande et al., 2007 |
| C-myc | VSMC proliferation | Rat model, in vitro | Wang et al., 2011 |
| Survivin | VSMC proliferation, migration and apoptosis resistance | In vitro | Nabzdyk et al., 2011 |
| AP-1 | VSMC proliferation, differentiation and migration, MMP expression | In vitro | Zhang et al., 2012 |
| Ptc-1 / Shh / GLI2 | VSMC proliferation, vascular remodeling | In vitro | Redmond et al., 2013; Li et al., 2010 |
| Immune Mediators | |||
| TLR4 | Inflammation | Mouse model | Zhang et al., 2011; Karper et al., 2011 |
| AIF-1 | VSMC proliferation | Mouse model | Sommerville et al., 2009 |
| IP-10 | Chemotaxis, antiangiogenesis | Rabbit model | Zuojun et al., 2012 |
| NF-kappaB | Inflammation | Rat model | Meng et al., 2013 |
| Matrix Proteinases | |||
| MMP-2/-9 | ECM remodeling, VSMC migration | In vitro | Turner et al., 2007; Hlawaty et al., 2009 |
| MT1-MMP | Serum induced VSMC proliferation | In vitro | Mountain et al., 2012 |
| ADAMTS-7 | ECM remodeling | Rat model | Wang et al., 2009 |
| Protein Kinases | |||
| CK1alphaLS | VSMC proliferation, ECM composition | Ex vivo | Panchenko et al., 2010 |
| PKCdelta | Loss of function impairs EC migration | In vitro | Bai et al., 2010 |
| MARKCS | VSMC migration and proliferation | In vitro | Monahan et al., 2009 |
| Cell Surface Molecules | |||
| Cav1 | eNOS signaling, VSMC proliferation | In vitro | Luo et al., 2010 |
| Cdh11 | VSMC migration | In vitro | Monahan et al., 2007 |
| Miscellaneous | |||
| SCN9A | VSMC migration | In vitro | Meguro et al., 2009 |
| TSP-2 | VSMC attachment | In vitro | Yoshida et al., 2011; Nabzdyk et al., 2014 |
| Girdin | VSMC migration, actin filament reorganization | Rabbit model, in vitro | Miyachi et al., 2013 |
| Galphaq | VSMC proliferation, MMP-9 expression | Mouse model, in vitro | Zou et al., 2013 |
| Rab5 | VSMC proliferation and migration | In vitro | Ma et al., 2010 |
| HuR | VSMC proliferation | In vitro | Pullmann et al., 2005 |