TABLE III.
Computational characterization of PDGF-BB transport (parameter estimation and difference computation with regard to experimental values for collagen and fibrin hydrogels considering four different conditions: (Case 1) the values obtained in the degradation experiments are assumed as degradation rates and binding is neglected; (Case 2) the degradation rates are accepted from the degradation experiments and binding ratios are fitted to reduce the average difference in both channels; (Case 3) binding is neglected and the degradation rates are fitted to reduce the average difference in both channels; (Case 4) both degradation and binding rates are fitted to reduce the average difference in both channels).
| Collagen | Fibrin | |||||||
|---|---|---|---|---|---|---|---|---|
| Case1 | Case2 | Case3 | Case4 | Case1 | Case2 | Case3 | Case4 | |
| Degradation rate, (10−6·s−1) | 9.97 | 9.97 | 4.00 | 3.00 | 9.97 | 9.97 | 1.00 | 3.00 |
| Binding rate, (10−6·s−1) | 0.00 | 0.00 | 0.00 | 10.00 | 0.00 | 0.00 | 0.00 | 0.10 |
| Addition channel difference (%) | 14.40 | 14.40 | 0.61 | 1.89 | 17.90 | 17.90 | 6.52 | 0.54 |
| Opposite channel difference (%) | 1.49 | 1.49 | 2.97 | 0.95 | 3.00 | 3.00 | 0.92 | 1.49 |
| Average difference (%) | 7.96 | 7.96 | 1.79 | 1.42 | 10.40 | 10.40 | 3.72 | 1.02 |