Table 4.

ROC AUC for Initial and Repeat Biopsies Comparing PCPT Model with PCPT Model Plus PCA3 After Correction by 10-Fold Cross Validation

Model	ROC AUC
	Any Cancer		HG Cancer
	Initial	Repeat	Initial	Repeat
PCPT	0.68	0.64	0.74	0.74
PCPT plus PCA3	0.79	0.69	0.78	0.79
Likelihood ratio test	< .001	< .001	< .001	.003

Abbreviations: AUC, area under the curve; HG, high-grade; PCA3, prostate cancer antigen 3; PCPT, Prostate Cancer Prevention Trial; ROC, receiver operating characteristic.