Figure 3.

Regional plots in ADCY3(adenylate cyclase 3) locus showing that the association at the locus is attributed to rs11676272. (a) BMI adjusted for height, age and sex in ALSPAC, (b) BMI adjusted for height, age and sex conditioning on rs11676272 in ALSPAC. Each circle represents a SNP plotted by its position on the chromosome against its association (−log10 P). The SNPs are colored according to their linkage disequilibrium (LD) with rs11676272 using pairwise r² values from HapMap CEU samples. The diagram in light blue represents the LD structure in the region. Data for gene structure from UCSC Genome Browser are shown below the diagram. Plots were generated using LocusZoom ²² [Avon Longitudinal Study of Parents and Children (ALSPAC)].