Table 2.
Accessibility of selected metabolite classes using reversed and HILIC stationary phases
| Compound class | C18 | HILIC |
|---|---|---|
| Acyl glycines | 62 | 63 |
| Amino acids | 64 | 65 |
| Amino alcohols | 64 | 64 |
| Bile acids | 66,67 | |
| Biotin and derivatives | 64 | 64 |
| Carbohydrates | 68 | |
| Carnitines | 69 | |
| Catecholamines and derivatives | 70 | |
| Cobalamin derivatives | 71 | |
| Coenzyme A derivatives | 64 | 64 |
| Dicarboxylic acids | 72 | 73 |
| Fatty acids | 74 | 75 |
| Glucuronides | 76 | 77 |
| Glycerolipids | 78 | 79 |
| Hydroxy acids | 80 | 81 |
| Indoles and indole derivatives | 82 | |
| Keto acids | 83,84 | 81 |
| Leukotrienes | 85 | |
| Lipoamides and derivatives | 86 | |
| Nucleosides | 87 | |
| Nucleotides | 65 | |
| Peptides | 88 | 89 |
| Phospholipids | 90 | 91 |
| Polyamines | 92 | |
| Polyphenols | 93 | |
| Porphyrins | 94 | |
| Prostanoids | 95 | |
| Pterins | 96 | 97 |
| Purines and purine derivatives | 64 | 64 |
| Pyridoxals and derivatives | 98 | |
| Pyrimidines and pyrimidine derivatives | 87 | |
| Retinoids | 99 | |
| Sphingolipids | 100 | 101 |
| Steroids and steroid derivatives | 102 | |
| Sugar phosphates | 103 | |
| Tricarboxylic acids | 104 |