Table 2.
Invitrogen kinase screening data
| Kinase | Percent inhibition at 1000 nm oclacitinib (1st replicate) | Percent inhibition at 1000 nm oclacitinib (2nd replicate) |
|---|---|---|
| ABL tyrosine kinase | 13 | 13 |
| RAC-alpha serine/threonine kinase (Protein kinase B) | 3 | 0 |
| ZAP-70 tyrosine kinase | 12 | 9 |
| Angiopoietin 1 receptor (TIE-2) (TEK) | 3 | −1 |
| Aurora-related kinase 1 (ARK1) | 40 | 40 |
| Ste20-like kinase MST2 | 22 | 14 |
| SRC kinase | 19 | 15 |
| Serum glucocorticoid-regulated kinase (SGK) (SGK1) | 16 | 11 |
| p160ROCK protein kinase | 34 | 32 |
| Protein kinase C beta II Isoform | 8 | 5 |
| Protein kinase A alpha | 19 | 14 |
| Serine/threonine protein kinase PIM-2 | 13 | 6 |
| PAK-4 (p21 activated kinase 4) | 18 | 9 |
| High affinity nerve growth factor receptor (TRK-A) | 32 | 31 |
| Serine/threonine protein kinase NEK2 | 4 | 3 |
| Myosin light chain kinase (skeletal) | 12 | −1 |
| Serine/threonine protein kinase MASK | 6 | 3 |
| Hepatocyte growth factor receptor (MET Proto-oncogene tyrosine kinase) | 21 | 9 |
| Serine/threonine protein kinase MARK | 43 | 40 |
| MAP kinase activated protein kinase 2 (MAPKAPK-2) | 6 | 0 |
| Mitogen-activated protein kinase 1 (MAPK1/ERK2) | 10 | 6 |
| Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4/HGK) | 42 | 34 |
| Proto-oncogene LCK tyrosine kinase | 22 | 22 |
| Vascular endothelial growth factor receptor 2 (VEGFR-2/FLK1) | 41 | 37 |
| Tyrosine-protein kinase JAK3 (JANUS KINASE 3) | 98 | 92 |
| Insulin receptor | 7 | 4 |
| Glycogen synthase kinase-3 beta (GSK-3 beta) | 9 | 8 |
| FGFR1 FGF receptor 1 | 12 | 8 |
| Ephrin type-A receptor 2 (ECK) | 9 | 2 |
| Epidermal growth factor receptor | 10 | 6 |
| Casein kinase II alpha prime chain (CK II) | 5 | 3 |
| Casein kinase 1, alpha 1 | 1 | 1 |
| Checkpoint kinase (CHK2) | 9 | 5 |
| Checkpoint kinase CHK1 | 21 | 6 |
| CDK2/Cyclin-A | 11 | 10 |
| Calcium/calmodulin-dependent protein kinase II alpha-B subunit | 22 | 15 |
| Bruton's tyrosine kinase (BTK) | 8 | 6 |
| TAO kinase 2 | 20 | -2 |
| Mitogen-activated protein kinase 14 (MAPK14/P38-alpha) | 9 | 7 |