Table 3.
Inhibitory activity of oclacitinib in cell model systems
| Assay | Mean IC50 (nm) ± SEM* |
|---|---|
| Canine IL-2 function in beagle whole blood | 63 ± 6 |
| Canine IL-2 function in mixed breed whole blood | 189 ± 39 |
| Human IL-4 function in cells | 249 ± 19 |
| Human IL-6 function in cells | 159 ± 58 |
| Human IL-13 function in cells | 113 ± 7 |
| Canine IL-31 function in cells | 36 ± 6 |
| Canine (beagle) erythropoietin function in cells | 1020 ± 189 |
| Human GM-CSF function in cells | 1090 ± 110 |
| Human IL-12 function in cells | >3000 |
| Human IL-23 function in cells | >3000 |
*
Arithmetic means representing the concentration of oclacitinib that inhibits activity by 50% (IC50) ± SEM (n = 2–24).