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. 2014 Nov 4;117(6):1549–1563. doi: 10.1111/jam.12662

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© 2014 The Authors published by John Wiley & Sons Ltd on behalf of Society for Applied Microbiology.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Selected xenobiotic substrates of CYP105s. (a) Sulfonylurea herbicide substrates of CYP105A1 from Streptomyces griseolus, (b) steroid substrates of CYP105C from Streptomyces virginiae IBL14, (c) reaction scheme for conversion of diosgenone to isonuatigenone by CYP105C from S. virginiae IBL14 and (d) substrates of CYP105D1 from S. griseus discussed in the text. Except in the case of diosgenone, where the modification is indicated, and 7-ethoxycoumarin, which is dealkylated, the site of modification by the CYP105 has not been identified.