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. 2014 Nov 4;117(6):1549–1563. doi: 10.1111/jam.12662

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© 2014 The Authors published by John Wiley & Sons Ltd on behalf of Society for Applied Microbiology.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Crystal structures of CYP105D6 and CYP105P1 from Streptomyces avermitilis. (a) Overlaid cartoon representations of CYP105D6 (() D6, PDB 3ABB; Xu et al. 2010), CYP105P1 (() P1, PDB 3E5J; Xu et al. 2009) and CYP105P1 with bound filipin I (() P1 + filipin, PDB 3ABA; Xu et al. 2010). Haem and filipin I (from PDB 3ABA) shown as sticks. (b) Active site regions of CYP105D6 and CYP105P1, with residues responsible for the differing substrate specificity of the two enzymes (see text), bound haem and filipin I shown as sticks.

Inline graphic — Crystal structures of CYP105D6 and CYP105P1 from Streptomyces avermitilis. (a) Overlaid cartoon representations of CYP105D6 (() D6, PDB 3ABB; Xu et al. 2010), CYP105P1 (() P1, PDB 3E5J; Xu et al. 2009) and CYP105P1 with bound filipin I (() P1 + filipin, PDB 3ABA; Xu et al. 2010). Haem and filipin I (from PDB 3ABA) shown as sticks. (b) Active site regions of CYP105D6 and CYP105P1, with residues responsible for the differing substrate specificity of the two enzymes (see text), bound haem and filipin I shown as sticks.