Table 3.
Studies evaluating the link between 18F-FDG PET and vascular inflammation
| Type of study | Timing of analysis | Quantification methodology | Validation technique | |
|---|---|---|---|---|
| Rudd et al 3 | Clinical carotid (n=3) | Ex vivo: descriptive | Ex vivo 3H-deoxy glucose uptake detected by autoradiography in CD68-rich sections of carotid endarterectomy samples | |
| Ogawa et al 32 | Pre-clinical aorta (Rabbit) | 4 hours | Ex vivo: differential Uptake Ratio: (tissue activity/tissue weight)/(injected radiotracer activity/animal body weight) | Ex vivo gamma- well counting vs number of macrophages on histological sections |
| Tawakol et al 33 | Pre-clinical aorta (Rabbit) | 3 hours | In vivo: SUV(mean?) (decay-corrected tissue concentration
in KBq per milliliter, divided by the injected dose per body weight in KBq per
gram) Ex vivo: % injected dose/gram |
In vivo imaging or ex vivo gamma-well counting vs % area of macrophage immunostaining on histological sections |
| Hyafil et al 34 | Pre-clinical aorta (Rabbit) | 3 hours | In vivo: SUV mean | In vivo imaging vs % area of macrophage immunostaining on histological sections |
| Tawakol et al 35 | Clinical carotid (n=17) | 3 hours | In vivo: TBR (SUV mean divided by venous blood SUV mean) | In vivo imaging vs % area of macrophage immunostaining on histological sections |
| Figueroa et al 12 | Clinical carotid (n=10 from a previous study) | 1.5–3 hours | In vivo: TBR (SUV max measured at 5 mm intervals along the long axis of the carotid artery divided by venous blood SUV mean) | In vivo imaging vs % or total area of macrophage immunostaining on histological sections |
| Font et al 36 | Clinical carotid (n=15) | 30–45 minutes | In vivo: SUVmax for each plaque divided by the “average of the normal vessel wall values” | In vivo imaging vs % area of macrophage immunostaining on histological sections |
| Graebe et al 37 | Clinical carotid (n=10) | 3 hours | In vivo: TBR (mean SUVmax of the carotid artery divided by venous blood SUV mean) or SUV max | In vivo imaging vs CD68 mRNA level |
| Menezes at al 39 | Clinical carotid (n=21) | 90 minutes | In vivo: SUVmax | In vivo imaging vs % area of macrophage immunostaining on histological sections |
| Myers et al 40 | Multicenter clinical PAD (n=30) | 90 minutes | In vivo: mean of max TBR (mean of SUVmax divided by venous blood SUV mean) | In vivo imaging vs CD68 immunoassay |