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. 2014 Nov 24;2014:516069. doi: 10.1155/2014/516069

Table 2.

Combination levels of independent variables and the outcomes of response variables by Box-Behnken design.

Batch number Independent factors Actual value Predicted value
Capryol 90 HPMCAS-HF Aerosil 200 Mean globule size (nm) Encapsulation efficiency (%) Mean globule size (nm) Encapsulation efficiency (%)
P1 −1 −1 0 173.86 67.42 168.40 68.95
P2 +1 −1 0 194.84 96.18 189.01 94.68
P3 −1 +1 0 140.49 57.81 146.31 59.30
P4 +1 +1 0 172.06 59.15 177.51 57.61
P5 −1 0 −1 127.50 71.82 124.31 64.85
P6 +1 0 −1 180.02 67.05 177.20 63.11
P7 −1 0 +1 164.52 38.41 167.33 42.34
P8 +1 0 +1 163.07 61.16 166.25 68.12
P9 0 −1 −1 156.55 51.86 165.25 57.29
P10 0 +1 −1 164.35 39.90 161.70 45.36
P11 0 −1 +1 191.87 65.44 194.51 59.97
P12 0 +1 +1 173.07 30.61 164.43 25.18
P13 0 0 0 173.07 71.01 176.31 71.31
P14 0 0 0 180.91 70.79 176.31 71.31
P15 0 0 0 169.87 69.76 176.31 71.31
P16 0 0 0 184.81 75.05 176.31 71.31
P17 0 0 0 172.92 69.96 176.31 71.31

*Standard deviation of the observed responses was within ±5% (n = 3).