Table 2.

Combination levels of independent variables and the outcomes of response variables by Box-Behnken design.

Batch number	Independent factors			Actual value		Predicted value
	Capryol 90	HPMCAS-HF	Aerosil 200	Mean globule size (nm)	Encapsulation efficiency (%)	Mean globule size (nm)	Encapsulation efficiency (%)
P1	−1	−1	0	173.86	67.42	168.40	68.95
P2	+1	−1	0	194.84	96.18	189.01	94.68
P3	−1	+1	0	140.49	57.81	146.31	59.30
P4	+1	+1	0	172.06	59.15	177.51	57.61
P5	−1	0	−1	127.50	71.82	124.31	64.85
P6	+1	0	−1	180.02	67.05	177.20	63.11
P7	−1	0	+1	164.52	38.41	167.33	42.34
P8	+1	0	+1	163.07	61.16	166.25	68.12
P9	0	−1	−1	156.55	51.86	165.25	57.29
P10	0	+1	−1	164.35	39.90	161.70	45.36
P11	0	−1	+1	191.87	65.44	194.51	59.97
P12	0	+1	+1	173.07	30.61	164.43	25.18
P13	0	0	0	173.07	71.01	176.31	71.31
P14	0	0	0	180.91	70.79	176.31	71.31
P15	0	0	0	169.87	69.76	176.31	71.31
P16	0	0	0	184.81	75.05	176.31	71.31
P17	0	0	0	172.92	69.96	176.31	71.31

^*Standard deviation of the observed responses was within ±5% (n = 3).