TABLE 1.
Studies Included in the Pooled Analysis
Study | Phase | No. of Patients | Chemotherapy | Median TTP/PFS | Median OS |
---|---|---|---|---|---|
Ko 200617 | 2 | 51 | FDR gemcitabine + cisplatin | 3.9 mo (TTP) | 7.1 mo |
Ko 200818 | 2 | 52 | FDR gemcitabine + cisplatin + bevacizumab | 6.6 mo (TTP) | 8.2 mo |
Javle 200919 | 2 | 50 | Gemcitabine + capecitabine+ bevacizumab | 5.8 mo (PFS) | 4.8 mo |
Fogelman 201120 | 2 | 50 | FDR gemcitabine + oxaliplatin + bevacizumab | 4.9 mo (PFS) | 11.9 mo |
Hill 201121 | 1 | 21 | FDR gemcitabine + capecitabine + docetaxel | 5.8 mo (PFS) | 7.4 mo |
Martin 201216 | 2 | 42 | FDR gemcitabine + infusional 5-FU + bevacizumab | 5.9 mo (PFS) | 7.4 mo |
Ko 201222 | 1 | 45 | FDR gemcitabine + capecitabine | 5.5 mo (TTP) | 9.8 mo |
Abbreviations: 5-FU, 5-fluorouracil; FDR, fixed dose rate; OS, overall survival; PFS, progression-free survival; TTP, time to disease progression.