Table 5.

Associations between P2RX7 gene Tag SNP haplotypes and clinical data

		PPLpre
	Haplotypes	Coefficient	SE	CI	z-score	pvalue
1	ACGGAC	13.245	6.576	(0.357, 26.134)	2.014	0.044
2	GCGGAC	-0.23	4.252	(-8.563, 8.103)	-0.05	0.957
3	GTAAAC	-7.275	2.34	(-11.860, -2.689)	-3.11	0.002
		Analgesic effect (PPLpost-PPLpre)
		Coefficient	SE	CI	z-score	p value
1	ACGGAC	19.452	9.34	(1.146, 37.759)	2.083	0.037
2	GCGGAC	-2.966	6.87	(-16.431, 10.499)	-0.43	0.666
3	GTAAAC	-14.97	4.585	(-23.957, -5.983)	-3.27	0.001
		VAS pain score at 24 h
		Coefficient	SE	CI	z-score	p value
1	ACGGAC	7.878	4.067	(-0.094, 15.849)	1.937	0.053
2	GCGGAC	-10.799	3.523	(-17.705, -3.894)	-3.07	0.002
3	GTAAAC	7.434	8.88	(-9.971, 24.839)	0.837	0.402

Haplotype-based associations were tested using linear regression analyses with a recessive model.