Table 3.
Comparison between patients with low and high Sclerostin
| Variable | Low Scl (< 0.88 ng/ml) N = 45 | High Scl (≥ 0.88 ng/ml) N = 46 | p |
|---|---|---|---|
| Calcitonin, pg/ml | 2.3 (2.0, 3.4) | 3.5 (2.0, 6.0) | 0.082 |
| Age, years | 42 ± 18 | 43 ± 20 | 0.966 |
| Gender M/F | 24/22 | 31/14 | 0.103 |
| Diabetes, n | 7 | 7 | 0.964 |
| Dialysis vintage, mos | 84 (36, 144) | 144 (75, 180) | 0.049 |
| Creatinine, mg/dl | 10.7 ± 3.6 | 11.3 ± 3.1 | 0.372 |
| AP, U/l | 106.9 ± 93.2 | 108.8 ± 72.6 | 0.984 |
| Calcium, mg/dl | 9.2 ± 1.0 | 9.2 ± 1.2 | 0.707 |
| Phosphate, mg/dl | 5.3 ± 1.7 | 5.2 ± 2.1 | 0.877 |
| Hemoglobin, g/dl | 11.7 ± 1.3 | 11.4 ± 1.8 | 0.468 |
| PTH, pg/ml | 133 (92, 363) | 204 (91, 297) | 0.835 |
| Albumin, g/dl | 4.1 ± 0.4 | 4.2 ± 0.5 | 0.224 |
| Ferritin, ng/ml | 558 (203, 851) | 510 (196, 717) | 0.685 |
| β2micro, μg/ml | 25.3 ± 9.6 | 30.0 ± 10.4 | 0.016 |
| IL-6, pg/ml | 2.6 (1.6, 3.8) | 3.2 (1.9, 6.7) | 0.112 |
| Klotho, pg/ml | 40.5 (4.6, 83.3) | 40.8 (0.1, 84.6) | 0.852 |
| FGF 23, RU/ml | 134 (123, 145) | 149 (127, 212) | 0.007 |
| All-Cause mortality, n | 8 | 18 | 0.012 |
| CV mortality, n | 1 | 15 | 0.0001 |
AP: Alkaline Phosphatase; PTH: parathormone; β2micro: β2microglobulin; IL-6: interleucin; FGF 23, fibroblast growth factor; CV: cardiovascular.