Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Dec 2;14:901. doi: 10.1186/1471-2407-14-901

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Antony et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

ST6GAL1 promoter hypermethylation in primary human bladder cancer is associated with loss of ST6GAL1 mRNA expression. (A) Representative MSP results of the ST6GAL1 promoter methylation status in four papillary non-invasive pTa low grade tumors (PAP) as well as four invasive high grade bladder cancer (INV) samples in comparison to four normal tissue specimens (NU). Bands labeled with U and M show unmethylated and methylated DNA, respectively. Percent values reflect methylation frequency (M frequency). Bisulphite-converted unmethylated, genomic (U-co) and polymethylated, genomic (M-co) DNA were used as positive controls. DNA control: genomic, non- bisulphite-converted DNA, NTC: non-template control. (B) Box plot illustrating ST6GAL1 mRNA downregulation according to hypermethylated ST6GAL1 promoter status in bladder cancer (UC). (U): unmethylated tumors. (M): Methylated tumors. Horizontal lines: grouped medians. Boxes: 25–75% quartiles. Vertical lines: range, peak and minimum; *p < 0.05.