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. 2014 Dec 2;14:901. doi: 10.1186/1471-2407-14-901

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© Antony et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Tumor-specific ST6GAL1 promoter hypermethylation is associated with ST6GAL1 gene silencing in an independent TCGA data set. (A) ST6GAL1 expression in bladder tumor samples from the TCGA data portal. Red: high expression, black: mean expression and green: low expression. Left panel: sample type (dark grey: primary tumor; white: solid normal tissues). Right panel: ST6GAL1 mRNA expression. (B) DNA methylation of the ST6GAL1 promoter analyzed in bladder cancer samples from TCGA data portal. Red: high methylation, white: mean methylation; blue: low methylation. Right panel: sample type (dark grey: primary tumor; white: solid normal tissues). Left panels: values of ST6GAL1 DNA methylation for each available CG number. The relative positions of six analyzed CpG duplets within the ST6GAL1 promoter region covering the MSP analyzed region (+224 to +346) are indicated. +1: ST6GAL1 TSS. CG25372568 position in relation to the stated TSS: +272. (C) Inverse correlation of ST6GAL1 mRNA expression and its DNA methylation status in primary bladder cancer samples. ρ: Spearman correlation coefficient.