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. 2014 Dec 7;15(1):156. doi: 10.1186/s12931-014-0156-4

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© Qi et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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AICAR and Resveratrol increased the expression of muscle SirT1 in muscle tissue in COPD model rats. Muscle SirT1 (Control: n = 6; 0.55 ± 0.04; COPD/saline: n = 6, 0.44 ± 0.03; COPD/AICAR, n = 6, 0.73 ± 0.02; COPD/Resveratrol, n = 6, 0.73 ± 0.03). n.s. F _{1, 11} = 5.0, p = 0.051 comparing the control group to COPD/saline group. ***F _{2, 17} = 48.69, p < 0.001 comparing the COPD/saline group to COPD/AICAR and COPD/resveratrol group respectively. n.s. (not significant).