Table 11.

Amino acid substitution of the NEP

		NEP
		35	66	80	98
I	B Lee 40	S	A	S	I
	DSO 090114 2004	.	.	.	.
	DSO 090124 2004	.	.	.	.
	DSO 090131 2004	.	.	.	.
	DSO 090133 2004	.	.	.	.
	DSO 090134 2004	.	.	.	.
	DSO 090136 2004	.	.	.	.
	DSO 090138 2004	.	.	.	.
II	B Yamagata 16 1988	.	V	N	.
	B Victoria 02 1987	.	V	N	.
	B Singapore 04 1991	.	V	N	.
	B Singapore 11 1994	.	V	N	.
III	DSO 090117 2004	N	V	N	V
	DSO 0003 2009	N	V	N	V
	DSO 0005 2009	N	V	N	V
	DSO 0070 2009	N	V	N	V
	Rest of DSO Seq	.	V	N	V
	B Singapore 22 1998	.	V	N	V
	B Singapore 31 1998	.	V	N	V
	B Singapore 35 1998	.	V	N	V
	B Singapore 04 1991	.	V	N	V
	Vacc04S B Hong Kong 330 2001	.	V	N	V
	Vacc0405N 05S B Jilin 20 2003	.	V	N	V
	Vacc0405N 05S B Shanghai 361 2002	.	V	N	V
	Vacc0608NS B Malaysia 2506 2004	.	V	N	V
	Vacc0506N B Jiangsu 10 2003	.	V	N	V
	Vacc0809NS B Florida 4 2006	.	V	N	V
	Vacc0912NS B Brisbane 60 2008	.	V	N	V
	Vacc1213N B Wisconsin 01 2010	.	V	N	V

3 amino acids of the NS1 protein (34, 97 and 101) within the ISG15 binding site display variability. I: Specimens clustering in cluster I of the NS phylogenetic tree. II: Specimens clustering in cluster II of the NS phylogenetic tree. III: Specimens clustering in cluster III of the NS phylogenetic tree. Rest of DSO Specimens: rest of specimens sequenced in this study not individually listed in this table. Identical amino acids are marked by a dot (.).