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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Epilepsia. 2014 May 16;55(8):1292–1300. doi: 10.1111/epi.12648

Figure 1.

Figure 1

Differential characteristics of subjects with duplications or deletions/intragenic mutations of FOXG1 on 14q12. Infantile spasms with hypsarrhythmia (A) has been commonly described with duplications. Children with smaller 14q12 duplications are non-dysmorphic, and have autistic features (B). MRI in duplications of 14q12 show a normal gyral pattern and intact corpus callosum (C), while children with deletions/intragenic mutations of FOXG1 have hypoplasia of the corpus callosum (D), foreshortened frontal lobes with gyral simplification, postnatal microcephaly, and multiple neurodevelopmental disabilities (E).