Table 4.
Analysis for association of gout risk with lipid and apo B-associated traits in non-tophaceous gout (left) and gout excluding participants taking fenofibrate and statins (right)
| HU vs non-tophaceous gout | HU vs lipid-lowering excluded gout | |||
|---|---|---|---|---|
| Adjusted OR [95% CI] | P | Adjusted OR [95% CI] | P | |
| Total Tg (mmol/L) | ||||
| Europeans | 1.11 [0.55-2.26] | 0.77 | 1.30 [0.367-2.51] | 0.44 |
| Polynesians | 0.95 [0.50-1.80] | 0.88 | 1.16 [0.68-1.96] | 0.59 |
| Combined | 1.04 [0.72-1.50] | 0.82 | 1.24 [0.86-1.78] | 0.25 |
| Total FPLC Tg (mmol/L) | ||||
| Europeans | 3.64 [0.96-13.82] | 0.068 | 7.41 [1.42-38.56] | 0.017 |
| Polynesians | 1.05 [0.29-3.77] | 0.94 | 1.58 [0.62-4.05] | 0.34 |
| Combined | 1.78 [0.91-3.48] | 0.091 | 2.37 [1.17-4.83] | 0.017 |
| VLDL Tg (mmol/L) | ||||
| Europeans | 5.10 [0.97-26.81] | 0.054 | 26.15 [2.48-276.04] | 0.007 |
| Polynesians | 1.72 [0.37-7.96] | 0.49 | 3.18 [0.84-12.05] | 0.089 |
| Combined | 2.78 [1.13-6.79] | 0.025 | 4.77 [1.76-12.96] | 0.002 |
| Total apo B ( μmol/L) | ||||
| Europeans | 4.32 [0.86-21.69] | 0.075 | 3.17 [0.71-14.09] | 0.13 |
| Polynesians | 158.22 [1.95-1286.5] | 0.024 | 7.23 [0.28-189.08] | 0.24 |
| Combined | 11.58 [2.62-51.15] | 0.001 | 4.32 [1.17-15.93] | 0.028 |
| VLDL apo B (0.1 μmol/L) | ||||
| Europeans | 1.99 [0.67-5.91] | 0.22 | 1.85 [0.52-6.57] | 0.34 |
| Polynesians | 0.39 [0.04-3.82] | 0.42 | 1.80 [0.50-6.49] | 0.37 |
| Combined | 1.32 [0.63-2.77] | 0.46 | 1.64 [0.74-3.63] | 0.23 |
| VLDL Tg:VLDL apo B | ||||
| Europeans | 1.06 [0.93-1.21] | 0.39 | 1.05 [0.92-1.20] | 0.43 |
| Polynesians | 1.48 [1.02-2.15] | 0.041 | 1.11 [1.00-1.24] | 0.060 |
| Combined | 1.07 [1.01-1.15] | 0.029 | 1.07 [1.00-1.14] | 0.042 |
Adjusted for age, BMI, type 2 diabetes, SSB intake (drinks/day), alcohol intake (drinks/week), eGFR, hypertension and prescription of lipid-lowering medication for the non-tophaceous analysis. The Polynesian data are also adjusted by number of self-reported Polynesian grandparents. The combined analysis was additionally adjusted by ancestral group. HU: hyperuricaemia; OR: odds ratio; CI: confidence interval; Tg: triglyceride; FPLC: fast protein liquid chromatography; VLDL: very low-density lipoprotein; apo B: apolipoprotein B; BMI, body mass index; SSB: sugar-sweetened beverage; eGRF: estimated glomerular filtration rate.