Table 1.
Review of the most relevant literature on treatment of cheilitis granulomatosa
| Author, year of publication | Diagnosis | Number of cases | Therapy | Results |
|---|---|---|---|---|
| Martinez Martinez et al . 2012 [14] | CG | 6 | TCA sulfone, oral steroids, tetracyclines, hydroxychloroquine, amoxicillin-clavulanic acid | Moderate (1 recurrence) |
| Ruiz Villaverde and Sanchez, 2012 [15] | CG | 1 | Adalimumab | Good |
| Álvarez-Garrido et al ., 2011 [16] | CD + CG | 1 | Remicade | Good |
| Macaigne et al ., 2011 [17] | CD + CG | 1 | Remicade | Good |
| Sasaki et al ., 2011 [18] | CG | 1 | Dental treatment | Markedly improved |
| Kawakami et al ., 2008 [19] | CG | 1 | Corticosteroid ointment and oral tranilast | None |
| Paradentitis treatment | Good | |||
| Mignogna et al ., 2008 [9] | CD | 1 | TCA | Good |
| Inui, 2008 [20] | CG | 1 | Roxithromycin | Good |
| Ratzinger et al ., 2007 [21] | CG | 1 | Methylprednisolone, Clofazimine | Moderate |
| UG + CD | 1 | None | None | |
| MRS | 1 | Clofazimine | Good | |
| CG | 1 | Clofazimine | Good | |
| CG | 1 | Clofazimine | None | |
| CG | 1 | Clofazimine | Good | |
| MRS | 1 | Clofazimine | Good | |
| BG | 1 | Clofazimine | Good | |
| PG | 1 | Clofazimine | Good | |
| CG + CD | 1 | Methylprednisolone, Azathioprine | Good | |
| MRS | 1 | Methylprednisolone, Infliximab | Good | |
| CG | 1 | None | None | |
| CG + CD | 1 | Methylprednisolone, Azathioprine, Infliximab | Good | |
| PG + CD | 1 | Clofazimine | Good | |
| Tonkovic-Capin, 2006 [22] | CD +CG | 1 | Methotrexate | Good |
| Kruse-Losler et al ., 2005 [23] | MRS | 3 | Cheiloplasty | Good |
| CG | 4 | |||
| Bogenrieder et al ., 2003 [24] | CG + CD | 1 | Mesalazine, | Good |
| prednisolone per os | ||||
| Hegarty et al ., 2003 [25] | CD + CG | 5 | Thalidomide | Good |
| Sciubba et al ., 2003 [26] | MRS + oral granulomatosis | 7 | TCA chlorhexidine, | Moderate |
| CD + CG | 6 | TCA, systemic sulfasalazine/steroids | Moderate | |
| Kolokotronis et al ., 1997 [27] | CG | 5 | In 3 intralesional corticosteroids | Good |
| In 2 oral corticosteroids [2] | ||||
| Ochonisky et al ., 1992 [28] | CD | 1 | Hydroxychloroquine | Good |
| Krutchkoff and James, 1978 [29] | CG | 1 | TCA +cheiloplasty | Good |
CG, cheilitis granulomatosa; CD, Crohn’s disease; TCA, triamcinolone acetate intralesional injections; UG, uranitis granulomatosa; PG, pareitis granulomatosa; BG, blepharitis granulomatosa.
Results: none =no remission, moderate =partial remission, good =complete remission. MRS: Melkersson–Rosenthal syndrome.