Abstract
The formation of amino acids by the action of electric discharges on a mixture of methane, nitrogen, and water with traces of ammonia was studied in detail. The presence of glycine, alanine, α-amino-n-butyric acid, α-aminoisobutyric acid, valine, norvaline, isovaline, leucine, isoleucine, alloisoleucine, norleucine, proline, aspartic acid, glutamic acid, serine, threonine, allothreonine, α-hydroxy-γ-aminobutyric acid, and α,γ-diaminobutyric acid was confirmed by ion-exchange chromatography and gas chromatography-mass spectrometry. All of the primary α-amino acids found in the Murchison Meteorite have been synthesized by this electric discharge experiment.
Keywords: electric-discharge synthesis, gas chromatography-mass spectrometry, amino-acid analyzer
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Selected References
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- Abelson P. H. Chemical events on the primitive Earth. Proc Natl Acad Sci U S A. 1966 Jun;55(6):1365–1372. doi: 10.1073/pnas.55.6.1365. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bada J. L., Miller S. L. Ammonium ion concentration in the primitive ocean. Science. 1968 Jan 26;159(3813):423–425. doi: 10.1126/science.159.3813.423. [DOI] [PubMed] [Google Scholar]
- Bar-Nun A., Bar-Nun N., Bauer S. H., Sagan C. Shock synthesis of amino acids in simulated primitive environments. Science. 1970 Apr 24;168(3930):470–473. doi: 10.1126/science.168.3930.470. [DOI] [PubMed] [Google Scholar]
- Coggins J. R., Benoiton N. L. Determination of N-methylamino acids and their optical purity with an amino acid analyzer. J Chromatogr. 1970 Oct 21;52(2):251–256. doi: 10.1016/s0021-9673(01)96572-0. [DOI] [PubMed] [Google Scholar]
- Cronin J. R., Moore C. B. Amino Acid analyses of the murchison, murray, and allende carbonaceous chondrites. Science. 1971 Jun 25;172(3990):1327–1329. doi: 10.1126/science.172.3990.1327. [DOI] [PubMed] [Google Scholar]
- Fox S. W., Windsor C. R. Synthesis of amino acids by the heating of formaldehyde and ammonia. Science. 1970 Nov 27;170(3961):984–986. doi: 10.1126/science.170.3961.984. [DOI] [PubMed] [Google Scholar]
- HARADA K., FOX S. W. THERMAL SYNTHESIS OF NATURAL AMINO-ACIDS FROM A POSTULATED PRIMITIVE TERRESTRIAL ATMOSPHERE. Nature. 1964 Jan 25;201:335–336. doi: 10.1038/201335a0. [DOI] [PubMed] [Google Scholar]
- Kvenvolden K. A., Lawless J. G., Ponnamperuma C. Nonprotein amino acids in the murchison meteorite. Proc Natl Acad Sci U S A. 1971 Feb;68(2):486–490. doi: 10.1073/pnas.68.2.486. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kvenvolden K., Lawless J., Pering K., Peterson E., Flores J., Ponnamperuma C., Kaplan I. R., Moore C. Evidence for extraterrestrial amino-acids and hydrocarbons in the Murchison meteorite. Nature. 1970 Dec 5;228(5275):923–926. doi: 10.1038/228923a0. [DOI] [PubMed] [Google Scholar]
- MILLER S. L. A production of amino acids under possible primitive earth conditions. Science. 1953 May 15;117(3046):528–529. doi: 10.1126/science.117.3046.528. [DOI] [PubMed] [Google Scholar]
- MILLER S. L. The mechanism of synthesis of amino acids by electric discharges. Biochim Biophys Acta. 1957 Mar;23(3):480–489. doi: 10.1016/0006-3002(57)90366-9. [DOI] [PubMed] [Google Scholar]
- Matthews C. N., Moser R. E. Prebiological protein synthesis. Proc Natl Acad Sci U S A. 1966 Oct;56(4):1087–1094. doi: 10.1073/pnas.56.4.1087. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Oró J., Gibert J., Lichtenstein H., Wikstrom S., Flory D. A. Amino-acids, aliphatic and aromatic hydrocarbons in the Murchison Meteorite. Nature. 1971 Mar 12;230(5289):105–106. doi: 10.1038/230105a0. [DOI] [PubMed] [Google Scholar]
- WHITFIELD R. E. STERIC FACTORS IN THE CHEMISTRY OF POLYPEPTIDES, POLY-ALPHAAMINO ACIDS AND PROTEINS. Science. 1963 Nov 1;142(3592):577–579. doi: 10.1126/science.142.3592.577. [DOI] [PubMed] [Google Scholar]