Table 4.
Multivariable Logistic Regression for Exposure to SSRI/SNRIs
| Covariate | Level | OR | 95% CI | P value | |
|---|---|---|---|---|---|
| Depression Diathesis | |||||
| Depression Symptoms* | Yes vs. no | 1.68 | 1.29 | 2.19 | <0.001 |
| Family history of depression | Yes vs. no | 2.15 | 1.79 | 2.57 | <0.001 |
| Comorbidity Indicators | |||||
| Number of medicines currently taking | 5–9 vs. 0–4 | 2.20 | 1.57 | 3.08 | <0.001 |
| ≥10 vs. 0–4 | 3.32 | 2.33 | 4.73 | <0.001 | |
| Missing vs. 0–4 | 1.54 | 1.03 | 2.31 | 0.036 | |
| Pain management index | Adequately vs. under-treated | 1.07 | 0.82 | 1.40 | 0.605 |
| Missing vs. under-treated | 1.83 | 1.10 | 3.05 | 0.020 | |
| Exposure to steroids | Yes vs. no | 0.76 | 0.56 | 1.04 | 0.086 |
| Exposure to beta-blockers | Yes vs. no | 0.86 | 0.69 | 1.07 | 0.171 |
| Exposure to anxiolytics | Yes vs. no | 2.04 | 1.62 | 2.58 | <0.001 |
| Exposure to sedatives | Yes vs. no | 2.10 | 1.42 | 3.10 | <0.001 |
| Cancer Treatment Status | |||||
| Current cancer therapy | Within 1 month vs. no | 0.81 | 0.59 | 1.12 | 0.206 |
| Within 1 year vs. no | 0.89 | 0.67 | 1.18 | 0.418 | |
| >1 year vs. no | 1.58 | 1.19 | 2.11 | 0.002 | |
| Prior systemic therapy | Yes vs. no | 1.49 | 1.18 | 1.89 | 0.001 |
| Prior radiotherapy | Yes vs. no | 1.12 | 0.89 | 1.40 | 0.334 |
| Clinical and Demographic Factors | |||||
| Race/Ethnicity | Other vs. Non-Hispanic White | 0.49 | 0.34 | 0.71 | <0.001 |
| Sex | Male vs. female | 0.54 | 0.40 | 0.73 | <0.001 |
| Age | <55 vs. ≥55 | 1.24 | 1.00 | 1.53 | 0.046 |
| Duration of cancer | Continuous (years) | 0.99 | 0.97 | 1.02 | 0.451 |
| Disease status | Advanced vs. Non-advanced | 0.88 | 0.74 | 1.04 | 0.123 |
| ECOG PS | 1–4 vs. 0 | 0.92 | 0.74 | 1.15 | 0.454 |
| Weight loss in past 6 months | >5% vs. ≤5% | 0.83 | 0.57 | 1.21 | 0.341 |
| Participation in a support group | Yes vs. no | 1.12 | 0.79 | 1.59 | 0.522 |
| Participation in counseling service | Yes vs. no | 1.61 | 1.02 | 2.54 | 0.041 |
| Perceived QOL | Poor vs. good | 1.32 | 1.05 | 1.65 | 0.016 |
| Type of institution | CCOP vs. academic | 1.80 | 1.14 | 2.83 | 0.012 |
| MBCCOP vs. academic | 1.47 | 0.78 | 2.80 | 0.236 | |
Abbreviations: OR: odds ratio, CI, confidence interval; ECOG PS, Eastern Cooperative Oncology Group performance status; QOL, quality of life; CCOP, Community Clinical Oncology Program; MBCCOP, Minority-Based Community Clinical Oncology Program
*
Depressive symptoms defined as combined results from case-finding categories 1–5 (depressive by any method).