Table II.

Focus group interview guide

#	Questions	Probes
1.	PrEP Adherence Content What topics would be important to discuss?	How would this content be disseminated? What type of personnel would be most effective?
2.	Barriers to PrEP Adherence What are some of the barriers to taking PrEP on a daily basis?	Side effects (e.g., nausea, diarrhea) Mood Substance use Economic/occupation/familial concerns
3.	Facilitators of PrEP Adherence What do you do to help you remember to take your pills on a regular basis?	Which novel ways would be acceptable to remind you to take PrEP as prescribed? PrEP Experienced: What did you do?
4.	PrEP and Sexual Decision-making How would taking PrEP affect your sex life?	How will taking PrEP affect: Your partner choice? Type of sex you would/will have (e.g., anal receptive or insertive)? Types of partners (e.g., anonymous, casual, serodiscordant, etc.)?
5.	Feasibility and Acceptability of the PrEP Adherence Intervention How willing do you think MSM at high risk of HIV infection would be to engage in counseling around PrEP adherence and sexual risk?	Would you prefer to have the same person counsel you about adherence as the person who would provide risk reduction counseling? Would you prefer to record your adherence using a computer program or with study staff? What challenges might there be to discuss adherence with study staff?

PrEP = pre-exposure prophylaxis