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Characterization of thiol conjugate addition reactions with cyanoacrylamides. (a) Reaction of cyanoacrylamide 1 with BME is accompanied by a decrease in the 340 nm absorption band. (b) The Kd is determined by fitting the titration data to a simple one-site binding model. (c) Dilution of the BME/cyanoacrylamide adduct into buffer lacking BME establishes a new equilibrium favoring the cyanoacrylamide.
