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. 2014 Dec 15;28(24):2764–2777. doi: 10.1101/gad.251371.114

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© 2014 Omelchenko et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — AVE collective migration in the early mouse embryo. Transgenic embryos (E5.5–E6.5) expressing the indicated transgenes were imaged by DIC and confocal time-lapse microscopy. (A) Sagittal sections showing AVE (Hex-GFP) cells migrating over epiblast (GFP-GPI) cells. Schematic (left) and maximal projections (right) of four optical sections (6-μm thickness) taken from time-lapse snaphots (from Supplemental Movie S1). (Epi) Epiblast; (DVE) distal VE. A morphologically distinct, highly columnar subpopulation of VE cells expressing the Hex-GFP marker (green) and located at the distal end (DVE) move on the presumptive anterior side (red arrow), arrive at the embryonic/ExE border (red line), and become AVE. (B) Schematic (left) and optical projections (right) from time-lapse snapshots (10-μm thickness) of migrating Hex-GFP cells (green) moving on the ECM (magenta line). Long protrusions intercalate between front VE cells and the epiblast (red arrow).