Fig. 1.

Individual levels of S-nitrosothiol (RSNO) in plasma of healthy controls, Raynaud's phenomenon (RP), SSc systemic sclerosis (SSc), lcSSc (limited SSc) and dcSSc (diffuse cutaneous disease) patients. RSNO levels were detected by a NO chemiluminescence detector (NOA 280, Sievers). Horizontal bars represent median values observed in each group. Results obtain in each group were compared to the results obtained in healthy controls (one way ANOVA followed by the students Newman–Keuls test). P < 0.05 was considered statistically significant.