Table 3.
Association of Genome-Wide Significant Open-Angle Glaucoma Loci With 10-Year Incident Glaucoma in the Blue Mountains Eye Study
| Locus | CHR | SNP | Position (bp)a | A1/A2 | Frequency A1 |
Univariate Analysis |
Multivariate Analysisb |
|||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases | Controls | P Value | OR (95% CI) | P Value | OR (95% CI) | |||||
| TMCO1 | 1 | rs4656461 | 163953829 | G/A | 0.187 | 0.116 | .013 | 1.74 (1.12–2.72) | .022 | 1.79 (1.09–2.95) |
| CAV1/CAV2 | 7 | rs4236601 | 115949965 | A/G | 0.313 | 0.268 | .239 | 1.25 (0.86–1.81) | .329 | 1.21 (0.82–1.78) |
| 8q22 | 8 | rs1521774 | 106048166 | G/A | 0.366 | 0.324 | .314 | 1.20 (0.84–1.72) | .443 | 1.16 (0.80–1.67) |
| 9p21 | 9 | rs1063192 | 21993367 | A/G | 0.642 | 0.549 | .033 | 1.47 (1.03–2.11) | .103 | 1.37 (0.94–2.01) |
| 9p21 | 9 | rs1412829 | 22033926 | A/G | 0.687 | 0.568 | .006 | 1.67 (1.15–2.42) | .025 | 1.57 (1.06–2.32) |
| 9p21 | 9 | rs4977756 | 22058652 | A/G | 0.687 | 0.591 | .027 | 1.52 (1.05–2.20) | .109 | 1.37 (0.93–2.02) |
| SIX1/SIX6 | 14 | rs10483727 | 60142628 | A/G | 0.508 | 0.384 | .004 | 1.66 (1.17–2.34) | .007 | 1.70 (1.16–2.50) |
A1 = allele 1; A2 = allele 2; CHR = chromosome; CI = confidence interval; OR = odds ratio; SNP = single nucleotide polymorphism.
a
SNP positions are given in genome assembly hg18 in base pairs (bp). All analyses are with respect to the reported open-angle glaucoma risk allele (A1).
b
Multivariate analysis is adjusted for baseline characteristics age, sex, mean intraocular pressure, cup-to-disc ratio and disc diameter of both eyes, and systolic and diastolic blood pressure.