Table 4.
Logistic Regression Model Showing Association of Each Clinical Variable and Associated Polymorphism With 10-Year Incident Open-Angle Glaucoma in the Blue Mountains Eye Study
| Variable | B | SE | P Value | OR (95% CI) |
|---|---|---|---|---|
| Female sex | 0.930 | 0.305 | .002 | 2.53 (1.39–4.61) |
| Age (y) | 0.064 | 0.017 | <.001 | 1.07 (1.03–1.10) |
| Mean IOP (mm Hg) | 0.217 | 0.048 | <.001 | 1.24 (1.13–1.36) |
| Mean VCDR | 0.827 | 0.135 | <.001 | 2.29 (1.76–2.98) |
| Mean DD (mm) | −1.803 | 0.838 | .031 | 0.17 (0.03–0.85) |
| Systolic BP (mm Hg) | −0.005 | 0.008 | .559 | 1.00 (0.98–1.01) |
| Diastolic BP (mm Hg) | 0.021 | 0.018 | .245 | 1.02 (0.99–1.06) |
| rs4656461 (no. of risk alleles) | 0.608 | 0.258 | .018 | 1.84 (1.11–3.04) |
| rs1412829 (no. of risk alleles) | 0.439 | 0.205 | .032 | 1.55 (1.04–2.32) |
| rs10483727 (no. of risk alleles) | 0.525 | 0.200 | .009 | 1.69 (1.14–2.50) |
| Constant | −16.221 | 2.348 |
B = maximum likelihood estimate; BP = blood pressure; CI = confidence interval; DD = disc diameter; IOP = intraocular pressure; OR = odds ratio; SE = standard error of B; VCDR = vertical cup-to-disc ratio.