Table 5.

Neural Network Ranking and Contribution to Risk Prediction of Variables Associated With 10-Year Incident Open-Angle Glaucoma Risk in the Blue Mountains Eye Study

Rank	Age Matched		Not Age Matched
	Variable	Contributiona	Variable	Contributiona
1	Mean VCDR	0.034777	Mean VCDR	0.041231
2	Mean IOP	0.030919	Age	0.031223
3	Female sex	0.008209	Mean IOP	0.028952
4	rs4656461	0.007138	rs10483727	0.004189
5	Diastolic BP	0.004934	Diastolic BP	0.004119
6	rs10483727	0.001923	Systolic BP	0.004102
7	rs4236601	0.001604	rs4656461	0.003295
8	rs1412829	0.000489	rs1412829	0.001517
9	Systolic BP	−0.00073	Mean DD	−0.00070
10	Mean DD	−0.00084	rs4236601	−0.00224
11	rs4977756	−0.00228	Sex	−0.00249
12	rs1063192	−0.00481	rs1063192	−0.00361
13	rs1521774	−0.00552	rs4977756	−0.00408
14	Age	−0.00748	rs1521774	−0.00922

BP = blood pressure; DD = disc diameter; IOP = intraocular pressure; VCDR = vertical cup-to-disc ratio.

^aThe contribution of each variable is defined as the reduction in neural network predictive error it confers.