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Models of the roles of CLASPs and KIF1C in podosome formation. (A) A model of podosome regulation by CLASP-dependent KIF1C transportation. Upon PDBu treatment, CLASP is recruited to MTs and stimulates KIF1C binding to MTs. This leads to KIF1C-dependent transport of essential factors to podosome formation sites. (B) A schematic representation of the proposed signaling cascade triggered by PDBu treatment.
