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. 2014 Dec 15;127(24):5317–5330. doi: 10.1242/jcs.157610

Fig. 1.

Fig. 1.

cGMP signaling components are localized to two distinct compartments in AFD neurons. (A,B) Fluorescently tagged membrane proteins in the cGMP signaling pathway are coexpressed with ARL-13, a ciliary membrane marker, driven by an AFD-specific promoter (gcy-8p). (A) SRTX-1 and GCY-18 are AFD-specific, and present within the finger membrane but not the cilium. (B) TAX-4 is expressed in many ciliated neurons besides AFD neurons, and is localized specifically to the proximal part of the AFD cilium (arrows). Two representative images are shown for TAX-4. (C) EGL-2, an EAG K+ channel, shows ring-like localization pattern at the base of the finger compartment in AFD neurons, as marked by SRTX-1. Schematics of the two compartments and localization of signaling components are depicted on the right of the panels (only six fingers are drawn, there are normally about 60). Scale bars: 1 µm.