Table 1.
Application of free aptamers as cancer-targeted therapeutics
| Aptamer | Target | Cancer | References |
|---|---|---|---|
| DNA aptamer | DNA-binding proteins | Ovarian cancer and breast cancer | Mern et al. 2010 88, 89 |
| DNA aptamer | MCF-10TA1 cell | Breast cancer | Tan et al. 2011 90 |
| DNA aptamer | VEGF165 protein | Human hepatocellular carcinoma | Yung et al. 201391 |
| DNA aptamer | AGE product | Melanoma | Yamagishi et al. 2014 92 |
| RNA aptamer | CEA protein | Colorectal cancer | Lee et al. 2012 93 |
| RNA aptamer | MDSC and TAM | Multiple carcinomas (colon, mammary, fibrosarcoma, melanoma) | Serafini et al. 2012 85 |
AGE, advanced glycation end; CEA, carcinoembryonic antigen; MDSC, myeloid-derived suppressor cells; TAM, tumor-associated macrophage; VEGF, vascular endothelial growth factor.