Table 2.
Application of aptamer-drug conjugations as cancer-targeted therapeutics
| Aptamer | Target | Drug | Cancer | Research Group |
|---|---|---|---|---|
| DNA aptamer | CCRF-CEM cell | DOX | T-cell ALL | Tan et al. 2009 100 |
| DNA aptamer | LH86 cell | DOX | Human hepatocellular carcinoma | Tan et al. 2012 52 |
| DNA aptamer | MUC1 protein | DOX | Lung cancer and breast cancer | Yang et al. 2012 101 |
| DNA aptamer | HER2 protein | DOX | Breast cancer | Yang et al. 2012 102 |
| RNA aptamer | EpCAM protein | DOX | Retinoblastoma | Krishnakumar et al. 2012 103 |
| RNA aptamer | EGFR protein | GEM | Pancreatic cancer | White et al. 2012 104 |
ALL: acute lymphoblastic leukemia; CCRF-CEM, T-acute lymphoblastic leukemia cell line; GEM, gemcitabine; LH86, human hepatocellular carcinoma cell line.