Figure 1.

Targeted delivery of nanoparticles into mouse mammary tumors using targeting ligand conjugated IONPs. A. NIR 830 dye labeled ATF peptides, single chain antibody ScFvEGFR, or non-targeted control MSA were conjugated to amphiphilic polymer coated IONPs, resulting in dual optical and MR imaging modality nanoparticles. Near infrared optical imaging was performed 48 hours following the tail vein injection of the nanoparticles using the Kodak FX in vivo imaging system. Arrows: orthotopic 4T1 mouse mammary tumors. B. Prussian blue staining. Frozen tumor tissue sections were used. Blue: IONP positive cells; Red: nuclear fast red background staining.