Table 3.
Comparison of sensitivity for different DNA assay methods based on MNPs.
| Analytical method | Label | Detection limit |
|---|---|---|
| Colorimetric detection | Ag/SiO2 | 100 pM 71 |
| Colorimetric detection | Carbon nanotube-HRP | 1 pM 72 |
| Surface plasma resonance (SPR) | Label-free | 10-100 pM 73 |
| Quartz crystal microbalance (QCM) | Gold nanoparticle | 32 pM 74 |
| MNPs-electrochemical | Gold nanoparticle | 6 pM 75 |
| Inductively coupled plasma mass spectrometry (ICPMS) | Gold nanoparticle | 200 fM 76 |
| Magnetic concentration-fluorescence | Quantum dots | 500 fM 77 |
| Fluorescence imaging | Counting silica nanoparticles | 0.8 fM 78 |
| MNPs-CL | Catalytic DNAzyme | 100 pM 56 |
| MNPs-CL | Gold nanoparticle | 1 pM 58 |
| MNPs-CL | Horseradish peroxidase (HRP) | 100 fM 57 |
| MNPs-CL | Alkaline phosphatase | 5 pM 62 |
| MNPs-CL (this work) | Alkaline phosphatase | 10 fM |