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The CX3CL1 molecule is quasi-immobile due to the high glycosylation of its mucin stalk and the multimerization driven by its TM domain. The oligomer molecule is catching mobile CX3CR1 receptors through binding to its CD (chemokine domain) thanks to the flexible and stretched mucin stalk. The robustness of the adhesion is ensured by the CX3CL1 cytosolic domain anchoring it to the cytoskeleton.
