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. 2014 Nov 28;3(12):1228–1235. doi: 10.1242/bio.201410132

Fig. 5. β1 integrin-dependent signaling is regulated by a balance between fluid shear stress and CCM complex.

Fig. 5.

(A) Activated-state-specific β1-integrin and F-actin staining of HUVEC exposed to fluid shear stress at 2.0 Pa for 18 h or under static conditions and CCM2-silenced HUVEC under static conditions. White arrow: indicates the direction of flow. (B) Silencing of CCM2 by siRNA in HUVEC analyzed by western blot. (C) Elongation of CT- or CCM2-silenced HUVEC under static conditions. Data are means ± SE (N = 3), *p<0.05. (D) Shear stress and CCM complex act antagonistically on β1 integrin-dependent morphological response of EC. Scale bar: 10 µm (A).